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This article originally appeared at https://gut.bmj.com/content/54/12/1741.abstract Authors: Abstract Background and aims: Cyclooxygenase 2 (COX-2) is upregulated in most colorectal cancers and is responsible for metabolism of the endogenous cannabinoid, anandamide, into prostaglandin-ethanolamides (PG-EAs). The aims of this study were to determine whether anandamide and PG-EAs induce cell death in colorectal carcinoma (CRC) cells, and whether high…

This article originally appeared at https://www.pnas.org/doi/abs/10.1073/pnas.95.14.8375 Authors: Luciano De Petrocellis, Dominique Melck, Antonella Palmisano, +3, and Vincenzo Di MarzoAuthors Info & Affiliations July 7, 1998 https://doi.org/10.1073/pnas.95.14.8375 Abstract Anandamide was the first brain metabolite shown to act as a ligand of “central” CB1 cannabinoid receptors. Here we report that the endogenous cannabinoid potently and selectively inhibits the proliferation of human breast cancer cells in vitro….

This article originally appeared at https://www.jneurosci.org/content/25/8/1904.abstract Authors: Belén G. Ramírez, Cristina Blázquez, Teresa Gómez del Pulgar, Manuel Guzmán and María L. de Ceballos Journal of Neuroscience 23 February 2005, 25 (8) 1904-1913; DOI: https://doi.org/10.1523/JNEUROSCI.4540-04.2005 Abstract Alzheimer’s disease (AD) is characterized by enhanced β-amyloid peptide (βA) deposition along with glial activation in senile plaques, selective neuronal loss, and cognitive deficits. Cannabinoids are neuroprotective agents against excitotoxicity in…

This article originally appeared at https://cfah.org/marijuana-statistics/#thm Report Highlights: The United States cannabis industry has grown stronger over the past few decades. It even surpassed expectations. This U.S. marijuana statistics report shows you how the cannabis landscape has changed over the years. It will also give you a glimpse of its future. How Many People Smoke…

This article originally appeared at https://www.pnas.org/doi/full/10.1073/pnas.160105897 Authors: A. M. Malfait, R. Gallily, P. F. Sumariwalla, +3, and M. FeldmannAuthors Info & Affiliations August 1, 2000 https://doi.org/10.1073/pnas.160105897 Abstract The therapeutic potential of cannabidiol (CBD), the major nonpsychoactive component of cannabis, was explored in murine collagen-induced arthritis (CIA). CIA was elicited by immunizing DBA/1 mice with type II collagen (CII) in complete Freund’s adjuvant. The…

Pharmacology 21: 175-185 (1980) Jomar M. Cunha, E.A. Carlini, Aparecido E. Pereira, Oswaldo L. Ramos,Camilo Pimentel, Rubens Gagliardi, W.L. Sanvito, N. Lander and R. Mechoulam Departments de Psicobiologia, Departamento de Medicina, Departamento deNeurologia, Escola Paulista de Medicina; Departamento de Neurologia,Faculdade de Medicina da Santa Case, Sao Paulo, [Brazil] and Department ofNatural Products, Pharmacy School, Hebrew…

This article originally appeared at https://www.vice.com/en/article/7xz83x/the-deeply-unchill-things-that-happened-when-i-tried-to-quit-weed One cliché that I know about is that “things change in an instant.” Another cliché that I know about is that clichés are true. Three Saturdays ago, I spent the entire day in bed, constantly packing bowls of weed, compulsorily smoking them, and watching increasingly bleak and uninteresting TV…

This article originally appeared at https://www.popsci.com/marijuana-psychosis/ Reefer madness—the idea that marijuana drives most of its users to commit crimes and descend into sin—is an ableist morality fable. But for a specific population of marijuana users, there is a link between pot use and mental health. A study published yesterday in The Lancet Psychiatry underlines that link as well as providing…

This article originally appeared at https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0156614 “I Use Weed for My ADHD”: A Qualitative Analysis of Online Forum Discussions on Cannabis Use and ADHD Background Attention-deficit/hyperactivity disorder (ADHD) is a risk factor for problematic cannabis use. However, clinical and anecdotal evidence suggest an increasingly popular perception that cannabis is therapeutic for ADHD, including via online…

This article originally appeared at https://www.science.org/content/article/oldest-evidence-marijuana-use-discovered-2500-year-old-cemetery-peaks-western-china Oldest evidence of marijuana use discovered in 2500-year-old cemetery in peaks of western China Today, more than 150 million people regularly smoke cannabis, making it one of the world’s most popular recreational drugs. But when and where humans began to appreciate the psychoactive properties of weed has been more…