CULTURE EXCLUSIVE: Cannabis and Cancer – The Stan Rutner Story
Cannabinoids for the Treatment of Chronic Non-Cancer Pain: An Updated Systematic Review of Randomized Controlled Trials
This originally appeared at https://pubmed.ncbi.nlm.nih.gov/25796592/ Abstract An updated systematic review of randomized con-trolled trials examining cannabinoids in the treatment ofchronic non-cancer pain was conducted according to PRISMA guidelines for systematic reviews reporting on health careoutcomes. Eleven trials published since our last review metinclusion criteria. The quality of the trials was excellent. Sev-en of the trials […]
Studies Showing an Anti-Cancer Effect
This is a mirror of the page at http://safeaccess.ca/research/cancer.htm A Population-Based Case-Control Study of Marijuana Use and Head and Neck Squamous Cell Carcinoma Caihua Liang,1 Michael D. McClean,3 Carmen Marsit,2 Brock Christensen,1,2 Edward Peters,4 Heather H. Nelson5 and Karl T. Kelsey1,2Cannabinoids, constituents of marijuana smoke, have been recognized to have potential antitumor properties. However, the […]
Research Suggests CBD’s Anxiety Relief Is Due To Neurogenesis
This article originally appeared at https://academic.oup.com/ijnp/article/16/6/1407/754216?login=false The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system Alline C. Campos, Zaira Ortega, Javier Palazuelos, Manoela V. Fogaça, Daniele C. Aguiar, Javier Díaz-Alonso, Silvia Ortega-Gutiérrez, Henar Vázquez-Villa, Fabricio A. Moreira, Manuel Guzmán … Show more International Journal of Neuropsychopharmacology, […]
Long-term behavioral and biochemical effects of an ultra-low dose of D9-tetrahydrocannabinol (THC) neuroprotection and ERK signaling
This article originally appeared at https://link.springer.com/article/10.1007/s00221-012-3186-5 Abstract We have previously reported that a singleinjection of an ultra-low dose of delta-9-tetrahydrocanna-binol (THC; the psychoactive ingredient of marijuana)protected the brain from pentylenentetrazole (PTZ)-induced cognitive deficits when applied 1–7 days before or1–3 days after the insult. In the present study we expandedthe protective profile of THC by showing […]
Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects
This originally appeared at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1253627/ Abstract The hippocampal dentate gyrus in the adult mammalian brain contains neural stem/progenitor cells (NS/PCs) capable of generating new neurons, i.e., neurogenesis. Most drugs of abuse examined to date decrease adult hippocampal neurogenesis, but the effects of cannabis (marijuana or cannabinoids) on hippocampal neurogenesis remain unknown. This study aimed at […]
Overview of the Endocannabinoid system.
Medicinal cannabis is routinely recommended for a wide variety of conditions. For example, in California, patients can qualify for cannabis medicine if they have AIDS, anorexia, arthritis, cachexia, cancer, chronic pain, glaucoma, migraines, muscle spasms, seizures, nausea, or other chronic symptoms. This begs the question – how can cannabis be recommended for so many different […]
Marijuana may be even safer than previously thought, researchers say
Compared with other recreational drugs — including alcohol — marijuana may be even safer than previously thought. And researchers may be systematically underestimating risks associated with alcohol use. Those are the top-line findings of recent research published in the journal Scientific Reports, a subsidiary of Nature. Researchers sought to quantify the risk of death associated with […]
Comparative risk assessment of alcohol,tobacco, cannabis and other illicit drugs using the margin of exposure approach
This originally appeared at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311234/pdf/srep08126.pdf A comparative risk assessment of drugs including alcohol and tobacco using the margin of exposure (MOE)approach was conducted. The MOE is defined as ratio between toxicological threshold (benchmark dose)and estimated human intake. Median lethal dose values from animal experiments were used to derive thebenchmark dose. The human intake was calculated […]
Daily Marijuana Use Is Not Associated with Brain Morphometric Measures in Adolescents or Adults
Barbara J. Weiland, Rachel E. Thayer, Brendan E. Depue, Amithrupa Sabbineni, Angela D. Bryan and Kent E. Hutchison Journal of Neuroscience 28 January 2015, 35 (4) 1505-1512; DOI: https://doi.org/10.1523/JNEUROSCI.2946-14.2015 Abstract Recent research has suggested that marijuana use is associated with volumetric and shape differences in subcortical structures, including the nucleus accumbens and amygdala, in a […]
